Lipid Science & Technology

Biography

Biography: Garth L. Nicolson

Abstract

Loss of function in mitochondria, the key cell organelle responsible for cellular energy production, can result in cell death, excess fatigue and other symptoms that are common problems in almost if not every chronic disease. These include:  neurodegenerative diseases , diabetes and metabolic syndrome, cardiovascular diseases, autoimmune diseases, neurobehavioral and psychiatric diseases, musculoskeletal and gastrointestinal diseases, fatiguing illnesses, cancer and chronic infections, among others. At the molecular level reduction in mitoc hondrial function occurs when there is loss of mitochondrial maintenance and inner membrane trans-membrane potential due to oxidative damage by Reactive Oxygen Species (ROS), resulting in reduced efficiency of the electron transport chain and less generation of ATP. Lipid Replacement Therapy (LRT) using an all-natural nutritional supplement mixture containing membrane glycerolphospholipids can be used to repair mitochondrial inner membrane damage, improve mitochondrial function, reverse ROS damage and increase the efficiency of the electron transport chain. Recent clinical trials have shown the benefits of Lipid Replacement Therapy in enhancing mitochondrial function, reducing fatigue and improving mood and cognition. For example, mitochondrial function and inner membrane trans-membrane potential has been enhanced by 25-35%, resulting in decreases in fatigue by 35-45% in chronically ill patients in clinical trials. LRT has also been used to reduce the adverse effects of cancer chemotherapy and improve symptoms other than fatigue in chronic illness patients.