Lipids-CS-2020

Lipid and Lipoprotein Metabolism

Lipoproteins can be produced endogenously in the liver with endogenous triglycerides and cholesterol in the hepatocytes, which are from chylomicron remnants. The LDL flows in the bloodstream and can be captivated by cells in the liver or peripheral tissues. The particles can fix to the target tissue with the LDL receptor with the engrossment of apolipoprotein B-100 which can then be engrossed by endocytosis, and the units hydrolyzed to discharge lipids such as cholesterol.

The total cost of reducing low-density lipoprotein includes the costs of physician services, lifestyle counseling, screening, case finding and monitoring, dietary and exercise modifications, medications, and treating side effects. The annual cost of statin drugs to reduce low-density lipoprotein cholesterol levels can range from $1,082 to $1,543 per year. The cost of follow-up or treatment-related appointments varies by type of provider, location, and practice setting. Although the cost of reducing low-density lipoprotein cholesterol levels can be high, it is much lower than the direct and indirect costs of cardiovascular disease research.