Lipids-CS-2020

Lipids in Signaling and Intracellular Trafficking

Lipid rafts/caveolae flagon designed constructions are opulent in proteins and furthermore lipids example: cholesterol and sphingolipids and have a rare volumes in signal transduction. They assume a part in disease cells advancement, endocytosis and the uptake of pathogenic microorganisms and certain infections. Ponders that have illustrated the part of lipid pontoons in flagging by means of bioreceptor tyrosine kinases and G protein-coupled receptors. The inositol phospholipids frame the basic premise for a mind boggling interchange of flagging reactions created, most regularly, by receptor actuation and bringing about changes in Ca +2 , protein kinase falls, and particle channel/exchanger movement. Phosphatidylinositol (PI) itself is a negligible phospholipid constituent of all eukaryote plasma films.

Understanding the mechanisms of intracellular trafficking and its interaction with other signaling molecules may lead to novel approaches in the treatment of a number of hematologic and other diseases. NIH has invested $127,980 in this specific area in 2015.